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The open questions about the short-term therapeutic success of carbapenems and a population-based economic analysis to calculate a potential saving in cost are to be addressed in future studies. As this study was intended to be a pilot project and did not include all patients with ESBL-producing *E. coli* infections (mostly due to practical limitations) and to investigate the *in vitro* susceptibility of carbapenemases in the routine situation, the study population was not powered to detect differences in clinical endpoints between patient groups. Further prospective studies are needed to confirm our results in terms of long-term therapeutic success and predictors for an individualized antibiotic strategy in cases of ESBL-producing *E. coli* infections.
Conclusion {#s5}
==========
In this study, short-term antibiotic treatment success was not associated with carbapenem MIC values in patients with ESBL-producing *E. coli* infections. A higher carbapenem MIC value is associated with higher failure rates, whereas the overall clinical success was not associated with the presence of a carbapenemase in *Enterobacteriaceae* isolates. In this cohort, neither the presence of a metallo-β-lactamase nor the source of the infection was associated with the risk of treatment failure. The current work is the first study to evaluate the *in vitro* susceptibility of carbapenems for ESBL-producing *E. coli* isolates in a real-life situation.
Data Availability Statement {#s6}
===========================
The datasets generated for this study are available on request to the corresponding author. 0b46394aab
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